Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors

Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors

Blog Article

Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold.Tightly packed repeats form a continuous hydrophobic core and a large groove-like solvent-accessible surface that creates a binding surface.DARPin domains recognizing a target of train sets interest with high specificity and affinity can be generated using a synthetic combinatorial library and in vitro selection methods.They can be linked together in a single molecule to build multispecific Bee Pollen and multifunctional proteins without affecting expression or function.The modular architecture of DARPins offers unprecedented possibilities of design and opens avenues for innovative antiviral strategies.